Imaging and genome-supported association of glymphatic system function and multiregional brain characteristics with Parkinson's disease - PubMed
5 hours ago
- #Parkinson's disease
- #Glymphatic system
- #Brain imaging
- Study investigates glymphatic system and brain characteristics in Parkinson's disease (PD).
- Lower ALPS index and elevated free water content in the temporal lobe are associated with PD.
- Combination of these markers provides high predictive accuracy for PD (AUC = 0.818).
- Mendelian randomization shows causal effects of frontal, occipital, parietal, and temporal lobes on PD risk.
- Findings suggest glymphatic dysfunction and brain alterations may improve early PD prediction.