Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits - PubMed
5 hours ago
- #Type 1 diabetes
- #Neurocognitive traits
- #Genetic correlation
- Type 1 diabetes, especially with childhood onset, is linked to altered neurocognitive traits.
- Genome-wide association studies show type 1 diabetes heritability is enriched in brain-resident cells like microglia.
- Negative genetic correlations found between type 1 diabetes and intelligence, executive function, and bipolar disorder.
- Positive genetic correlation observed between type 1 diabetes and myasthenia gravis.
- Pleiotropic loci identified, including the 17q21.31 neurogenomic hub, influencing both type 1 diabetes and neurocognitive traits.
- Mendelian randomization shows protective effects of educational attainment, intelligence, Alzheimer's disease, and bipolar disorder on type 1 diabetes risk.
- Liability to multiple sclerosis and myasthenia gravis increases type 1 diabetes risk.
- Type 1 diabetes liability is associated with increased risk of myasthenia gravis.
- Gene expression regulatory variants in brain and immune cells influence both type 1 diabetes and neurocognitive traits.
- Findings highlight shared genetic and neuroimmune mechanisms linking type 1 diabetes with cognition and neuropsychiatric disease risk.