The Effect of Acetylcholinesterase Inhibitors and N-Methyl-D-Aspartate Receptor Antagonists on the Risk of Development and Progression of Age-Related Macular Degeneration - PubMed
4 hours ago
- #neuroprotective drugs
- #drug repurposing
- #AMD progression
- Acetylcholinesterase inhibitors (donepezil, rivastigmine, galantamine) and memantine reduce risk of developing age-related macular degeneration (AMD) in AMD-naïve patients.
- Both drug types also lower the risk of progression from dry (nonexudative) to wet (exudative) AMD.
- Head-to-head comparisons show no significant difference in risk reduction between memantine and acetylcholinesterase inhibitors.
- Findings suggest neuroprotective pathways and potential for drug repurposing in AMD treatment.