Punicalagin Promotes Peripheral Nerve Repair by Enhancing Mitophagy via the TLR4/MAPK Signaling Pathway and Facilitating Angiogenesis - PubMed
5 hours ago
- #Peripheral Nerve Injury
- #Mitophagy
- #Angiogenesis
- Punicalagin (PUN) promotes peripheral nerve repair by enhancing mitophagy via the TLR4/MAPK signaling pathway and facilitating angiogenesis.
- PUN exhibits antioxidant and anti-inflammatory properties, attenuates ROS accumulation, and inhibits apoptosis in Schwann cells under oxidative stress.
- In vivo studies show PUN administration improves muscle preservation, axonal regeneration, remyelination, and functional recovery in rats with sciatic nerve injury.
- PUN's therapeutic effects are partially reversed by mitophagy inhibitors, highlighting its role in mitochondrial autophagy.
- Network pharmacology and molecular docking identify TLR4 as a primary target of PUN, modulating downstream MAPK signaling.
- PUN shows potential as a non-surgical therapeutic agent for peripheral nerve injury (PNI).