Astragalus Polysaccharide Alleviated Septic Associated Acute Kidney Injury Through Dual Mechanisms of RIPK1-Dependent Necroptosis and Autophagy in Macrophage - PubMed
5 hours ago
- #Astragalus polysaccharide
- #septic AKI
- #necroptosis
- Astragalus polysaccharide (AP) alleviates septic-associated acute kidney injury (SA-AKI) by targeting RIPK1-dependent necroptosis and autophagy in macrophages.
- AP improves renal dysfunction and reduces inflammation in LPS/zVAD-induced septic mice by inhibiting the RIPK1/RIPK3/MLKL pathway.
- AP promotes TFEB nuclear translocation, restoring autophagic flux in macrophages, which is crucial for its therapeutic effect.
- The study highlights AP's dual mechanism: suppressing necroptosis and enhancing autophagy, both dependent on RIPK1 modulation.
- Findings suggest AP as a potential natural therapeutic agent for SA-AKI with anti-inflammatory and immunoregulatory properties.