PD-1 blockade does not enhance alloimmunization after allogeneic dendritic cell vaccination in cancer patients - PubMed
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- #cancer-vaccine
- #PD-1-blockade
- PD-1 blockade does not enhance alloimmunization after allogeneic dendritic cell vaccination in cancer patients.
- 51.4% of patients developed anti-HLA antibodies, primarily dependent on the vaccine dose.
- Anti-HLA class II antibodies appeared earlier than class I antibodies.
- PD-1 blockade did not alter the magnitude, kinetics, or cytotoxic potential of the vaccine-induced humoral response.
- PD-1 signaling exerts a limited effect on antibody production and effector function during allogeneic human vaccination.