Tumor-Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis - PubMed
5 hours ago
- #exosomes
- #metastasis
- #gastric cancer
- Tumor-derived exosomes containing TAGLN2 promote metastasis in gastric cancer (GC).
- TAGLN2 is overexpressed in GC cells and tumor-associated endothelial cells (TECs), correlating with poor prognosis.
- Exosomal TAGLN2 induces angiogenesis, disrupts endothelial junctions, and causes vascular permeability.
- TAGLN2 upregulates NRP1 and SEMA4D, forming a ternary complex that activates YAP independently of the canonical pathway.
- Targeting the TAGLN2/NRP1/SEMA4D/YAP axis shows therapeutic potential in combination with cisplatin and bevacizumab.
- Exosomal TAGLN2 levels are elevated in GC patient serum, suggesting diagnostic utility.