Integrative Approaches to Treating Cellular Senescence in Kidney Disease - PubMed
5 hours ago
- #kidney disease
- #combination therapy
- #cellular senescence
- Cellular senescence in the kidney is crucial in the progression of acute kidney injury and chronic kidney disease.
- Current senolytic and senomorphic drugs show efficacy in preclinical models but have risks of adverse effects and only partially mitigate disease progression.
- Extracellular vesicles and longevity proteins like α-klotho and SIRT1 show potential in regulating cellular senescence and alleviating kidney fibrosis.
- Combination therapy targeting inflammation, tissue damage, and senescence simultaneously is promising for more effective kidney disease management.
- The review discusses mechanisms of cellular senescence in kidney disease, particularly diabetic kidney disease, and explores new therapeutic strategies.