Astrocytes at the crossroads of obstructive sleep apnea and Alzheimer's disease: from oxygen sensing to neurodegeneration - PubMed
7 hours ago
- #Alzheimer's Disease
- #Obstructive Sleep Apnea
- #Astrocytes
- Obstructive sleep apnea (OSA) is linked to cognitive decline and Alzheimer’s disease (AD).
- Astrocytes may serve as a mechanistic link between OSA and AD.
- Astrocytes respond to oxygen fluctuations and may become maladaptive under intermittent hypoxia, promoting oxidative stress and neuroinflammation.
- Epidemiological studies suggest a bidirectional association between OSA and AD.
- Targeting astrocyte-mediated mechanisms could provide insights into the OSA-AD link.