CLDN3 inhibits rotavirus attachment by targeting residue 74 of VP7 - PubMed
5 hours ago
- #CLDN3
- #rotavirus
- #VP7
- CLDN3 inhibits rotavirus (RV) attachment by interacting with VP7.
- RV infection disrupts CLDN3 localization to the plasma membrane and reduces its protein levels.
- Knockdown or knockout of CLDN3 promotes RV binding and entry.
- The CLDN3 EC1 loop interacts with the N-terminal domain of VP7, with residue E74 in VP7 being critical.
- The E74K mutation in VP7 disrupts CLDN3-VP7 interaction, enhancing viral attachment and pathogenicity.
- CLDN3 acts as a decoy receptor to counter VP7-mediated viral attachment.