Effect and potential mechanism of photobiomodulation therapy on cognitive deficits in animal models of Alzheimer's disease: a systematic review and meta-analysis - PubMed
6 hours ago
- #Alzheimer's disease
- #Meta-analysis
- #Photobiomodulation
- Photobiomodulation (PBM) therapy shows potential in improving cognitive function in Alzheimer's disease (AD) animal models.
- Meta-analysis of 16 studies indicates PBM significantly enhances learning ability and reduces Aβ deposition and p-Tau levels.
- PBM therapy enhances cytochrome c oxidase (CCO) activity, suggesting a mechanism involving mitochondrial function improvement.
- Greater cognitive improvements were observed in transgenic animal models and with specific PBM parameters (wavelength >750 nm, energy density ≤3 J/cm²).
- Preclinical evidence supports PBM's efficacy, but human translation requires optimization of treatment parameters and further high-quality trials.