The skin microbiome as a key regulator of psoriasis: From dysbiotic drivers to host-directed therapeutics - PubMed
4 hours ago
- #skin microbiome
- #psoriasis
- #dysbiosis
- The skin microbiome's dysbiosis is directly linked to psoriasis onset and progression, with increased pro-inflammatory bacteria like Corynebacterium and Staphylococcus aureus, and decreased beneficial microbes such as Cutibacterium.
- Microbial imbalances worsen psoriasis by damaging the skin barrier, disrupting immune responses, and altering microbial metabolites, highlighting key pathological mechanisms.
- Diagnostic approaches using microbiome signatures show promise for predicting disease subtypes, progression, and fluctuations, aiding in prognosis assessment.
- Future research should focus on multi-omics strategies to understand host-microbe interactions and develop personalized, microbiome-based therapies for psoriasis.