Short-Term Axial Length Changes Predict Progression of Myopic Maculopathy in Pediatric High Myopia - PubMed
5 hours ago
- #pediatric high myopia
- #myopic maculopathy
- #axial length
- Study objective was to characterize long-term myopic maculopathy (MM) progression and investigate short-term axial length (AL) and spherical equivalent (SE) changes as predictors in highly myopic children and adolescents.
- Prospective cohort study included 310 eyes from 155 highly myopic individuals aged 7-17 years with an 8-year follow-up.
- Ocular examinations were performed every two years, and MM was classified according to the Meta-PM system.
- Over 8 years, 31.29% of eyes showed MM progression, with the most common change being the new appearance of tessellated fundus (44.64%).
- Multivariable models showed that combining baseline AL and 2-year AL change rate provided superior predictive performance for long-term MM progression compared to baseline AL alone.
- The area under the receiver operating characteristic curve (AUC) values were 0.829 for the combined model and 0.772 for the baseline AL-only model.
- Similarly, the model incorporating baseline SE and 2-year SE change rate achieved a higher AUC (0.793) than the baseline SE model (AUC = 0.764).
- The predictive model demonstrated an optimism-corrected AUC of 0.821 based on bootstrap internal validation.
- The optimal cut-off value for the 2-year AL change rate was 0.325 mm/year.
- Nearly one-third of pediatric high myopes experienced MM progression over 8 years, highlighting the importance of early risk identification and timely intervention.