Persistent CD8+ T cell-driven immune dysregulation despite normalized CD4+ T cell recovery in ART-treated people living with HIV - PubMed
6 hours ago
- #CD8+ T cells
- #HIV
- #immune dysregulation
- Persistent CD8+ T cell-driven immune dysregulation occurs despite normalized CD4+ T cell recovery in ART-treated HIV patients.
- CD4/CD8 ratio inversion is primarily due to sustained CD8+ T cell expansion, reflecting chronic immune dysregulation.
- Study analyzed 5,416 ART-treated PLWH, identifying distinct CD8+ T cell trajectory groups (CSA vs. IMR).
- CSA group showed elevated CD8+ T cells, inverted CD4/CD8 ratios, and expanded senescent/activated CD8+ subsets.
- Bulk RNA sequencing revealed upregulated interferon-stimulated genes and pro-inflammatory pathways in the CSA group.
- Systemic levels of inflammatory mediators (IP-10, MCP-1, soluble CD163) were elevated in the CSA group.
- Persistent CD8+ T cell activation indicates a distinct immunological state with senescence, exhaustion, and inflammation.
- Findings may help identify individuals needing closer monitoring for non-AIDS complications.