Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease - PubMed
5 hours ago
- #Alzheimer's disease
- #neuromodulatory systems
- #sex differences
- Neuromodulatory subcortical systems (NSSs) are highly susceptible to dementia-related pathology, affecting molecular and behavioral functions.
- Some NSSs exhibit sex-specific cytoarchitecture and signaling, leading to distinct physiological and behavioral outcomes in males and females.
- The impact of sex differences on NSS dysfunction in Alzheimer's disease (AD) and related dementias is not well understood.
- This review explores sex differences in NSSs in both non-disease states and AD models/patients.
- NSSs may play a role in driving sex-specific susceptibility to AD, offering potential targets for sex-based interventions.
- The article outlines immediate and long-term actions to address the intersection of NSSs, sex, and AD.