Pinocembrin, an anticancer dihydroxyflavanone: from chemistry to cellular interactions and synergistic prospects - PubMed
6 hours ago
- #nanotechnology
- #anticancer
- #pinocembrin
- Pinocembrin is a natural flavanone with broad-spectrum anticancer potential, found in honey, propolis, and medicinal plants.
- It modulates cancer hallmarks by targeting PI3K/Akt/mTOR, STAT3, and NF-κB pathways, leading to antiproliferative, pro-apoptotic, anti-metastatic, and anti-inflammatory effects.
- Studies in various cancer models show it induces cell-cycle arrest, activates apoptosis, inhibits angiogenesis, and suppresses epithelial-mesenchymal transition.
- Structure-activity relationship analyses indicate modifications like hydroxylation and esterification can enhance its bioavailability and anticancer activity.
- Clinical use is limited by poor solubility and rapid metabolism, but nanotechnology-based formulations improve stability, delivery, and tumor targeting.
- Pinocembrin exhibits synergistic effects with conventional chemotherapies and has low toxicity to normal cells, making it suitable for combination therapy and chemoprevention.
- Preliminary clinical data show a favorable safety profile, though long-term toxicity and optimal dosing require further investigation.