Activation of GPR97/ADGRG3 by its tethered agonist, but not by beclomethasone, induces neutrophil polarization and migration - PubMed
4 days ago
- #neutrophil migration
- #GPR97
- #G protein-coupled receptors
- GPR97/ADGRG3 is activated by a tethered agonist mechanism, not by corticosteroids like beclomethasone.
- The receptor couples to G13, Gs, and Gi proteins but not to Gq, indicating promiscuous G protein coupling.
- Activation of GPR97 in neutrophils leads to cAMP production, cell polarization, and chemotaxis, effects not replicated by beclomethasone.
- The study highlights the role of GPR97/ADGRG3 in neutrophil migration through G protein signaling pathways.