A skin colonizer disrupts inflammatory and humoral immune defenses in hidradenitis suppurativa - PubMed
5 hours ago
- #Immune dysregulation
- #Porphyromonas uenonis
- #Hidradenitis suppurativa
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease linked to polybacterial dysbiosis.
- HS patients show IgA and IgG responses against skin colonizers, especially Porphyromonas uenonis (Pu), which is enriched in severe cases.
- Pu is found in the epidermis of HS patients, surrounded by IgA deposits, and anti-Pu IgGs cross-react with self-antigens in healthy keratinocytes.
- Patient-derived Pu can infect and persist within keratinocytes in healthy human skin explants, triggering pro-inflammatory mediators.
- In immunocompetent mice, topical Pu application elicits humoral immune responses without tissue infection.
- HS patients exhibit impaired innate immune control of Pu, linking keratinocyte infection to inflammation and humoral autoimmunity.
- Targeting cutaneous dysbiosis may help limit HS progression.