Alzheimers could be linked to a common virus
2 days ago
- #Herpes Simplex Virus
- #Alzheimer's Disease
- #Neurobiology
- The herpes simplex virus type 1 (HSV-1), commonly causing cold sores, may play a significant role in Alzheimer's disease.
- Research found HSV-1 DNA in the brains of Alzheimer's patients, linked to abnormal amyloid and tau protein production.
- Individuals with the APOE-e4 gene variant and HSV-1 infection have a significantly higher risk of developing Alzheimer's.
- Antiviral treatments in lab studies reduced brain damage, suggesting potential for slowing or preventing Alzheimer's.
- Population studies indicate severe HSV-1 infections are a strong predictor of Alzheimer's, with antivirals reducing risk.
- The shingles vaccine was found to lower dementia risk, supporting the idea that preventing infections could reduce Alzheimer's risk.
- Advanced 3D brain models showed infections or injuries can reactivate dormant HSV-1, causing Alzheimer's-like damage, preventable by reducing inflammation.
- The findings suggest vaccines or antivirals targeting dormant viruses could be new prevention strategies for Alzheimer's.