The ovarian tumor domain-containing protein 4 (OTUD4)-targeted ferroptosis inhibitor Maclekarpine E attenuates ulcerative colitis - PubMed
5 hours ago
- #OTUD4
- #Ulcerative Colitis
- #Ferroptosis
- Maclekarpine E (ME) shows potential as a treatment for ulcerative colitis (UC) by targeting ferroptosis.
- ME was prepared via a semi-synthetic and biomimetic route and tested in both in vitro and in vivo models.
- Proteomic analysis revealed ME inhibits ferroptosis by up-regulating the NRF2/GPX4 antioxidant axis and down-regulating ACSL4.
- ME binds to OTUD4, reducing GPX4 ubiquitination and enhancing its stability.
- The study suggests ME as a promising lead compound and OTUD4 as a potential new target for anti-inflammatory drugs.