Age and early life adversity shape heterogeneity of the epigenome across tissues in macaques - PubMed

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Study explores age and early life adversity (ELA) effects on DNA methylation across 14 tissues in 237 semi-free-ranging rhesus macaques.
Age-associated DNA methylation changes are predominantly tissue-dependent, but epigenetic aging is relatively consistent within individuals.
ELA effects are adversity-dependent and coordinated across tissues, targeting many of the same loci as age but in different directions, indicating ELA does not uniformly increase epigenetic age.
ELA leaves a distinct, cross-tissue epigenetic signature separate from yet intertwined with age-related differences, advancing understanding of how early environments shape aging and disease molecular foundations.

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