Plasma signals of lung tumor promotion for molecular cancer prevention - PubMed
4 hours ago
- #plasma proteomics
- #cancer prevention
- #lung cancer
- A 14-protein plasma signature predicts lung cancer more than 5 years before diagnosis.
- The signature is elevated in current smokers and those exposed to particulate matter, linked to lung myeloid and alveolar cells.
- In EGFR-driven lung adenocarcinoma, diverse epithelial lineages converge on a keratin8+/claudin4+ alveolar transitional state (KAC).
- Components of the signature are induced by particulate matter, oncogenic EGFR, or IL-1β, while IL-1β inhibition restrains KAC expansion and early tumorigenesis.
- In the CANTOS trial, the signature identified individuals who benefited more from anti-IL-1β therapy, lowering the number needed to treat.