Prebiotics attenuate depressive-like behavior, neuroinflammation and synaptic plasticity in Parkinson's disease by modulating butyrate-producing gut bacteria - PubMed
5 hours ago
- #Microbiota-gut-brain axis
- #Parkinson's disease
- #Neuroinflammation
- Prebiotics FOS and GOS alleviate depressive-like behavior and motor symptoms in Parkinson's disease (PD).
- Treatment increases brain serotonin and its receptor (SERT), and boosts butyrate-producing gut bacteria.
- Prebiotics reduce intestinal α-synuclein accumulation, inflammation, and improve gut barrier integrity.
- Neuroprotective effects include decreased neuroinflammation markers and preservation of dopaminergic neurons.
- Enhancement of synaptic plasticity via increased expression of BDNF, p-CREB, and synaptic protein PSD-95.
- Study suggests microbiota-gut-brain axis modulation as a therapeutic strategy for PD and depression.