Platycodin D alleviates idiopathic pulmonary fibrosis by targeting PPP2R1A and regulating the PP2A-mediated PI3K/Akt pathway to inhibit fibroblast transdifferentiation - PubMed
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- #Idiopathic pulmonary fibrosis
- #PI3K/Akt pathway
- #Platycodin D
- Platycodin D (PD) alleviates idiopathic pulmonary fibrosis (IPF) by targeting PPP2R1A.
- PD regulates the PP2A-mediated PI3K/Akt pathway to inhibit fibroblast transdifferentiation.
- PD reduces lung injury, inflammation, oxidative stress, and suppresses myofibroblast generation.
- PPP2R1A is identified as a critical target of PD through transcriptomics and Lip-SMap technology.
- PD binds to PPP2R1A, stabilizes and activates PP2A, inhibiting PI3K/Akt signaling.
- The inhibition of PI3K/Akt signaling by PD blocks myofibroblast transdifferentiation, alleviating IPF.