Anti-inflammatory effects of 1,8-cineol via NF-κB/COX-2 pathway in BEAS-2B cells and alleviates bronchoconstriction and airway hyperreactivity in ovalbumin sensitized mice - PubMed
5 hours ago
- #asthma inflammation
- #1,8-cineol
- #NF-κB/COX-2 pathway
- 1,8-cineol, derived from Eucalyptus, reduces inflammation and airway hyperreactivity in asthma models.
- In ovalbumin-sensitized mice, 1,8-cineol treatment improved lung compliance and lowered inflammatory markers like IgE, IL-4, IL-13, and IL-17.
- In BEAS-2B cells, 1,8-cineol inhibited TGF-β1-induced epithelial-mesenchymal transition (EMT) and cell migration without toxicity.
- The anti-inflammatory mechanism involves downregulation of the NF-κB/COX-2 signaling pathway, reducing phosphorylation and expression.
- The study suggests 1,8-cineol has therapeutic potential for asthma by targeting airway remodeling and inflammation.