HERPUD1 suppresses porcine epidemic diarrhea virus replication by recruiting HRD1 to degrade viral ORF3 protein - PubMed
6 hours ago
- #ER stress
- #HERPUD1
- #PEDV
- HERPUD1 suppresses PEDV replication by recruiting HRD1 to degrade the viral ORF3 protein via ERAD.
- ORF3 protein induces ER stress and inhibits IFN-β; its degradation by HERPUD1 alleviates this stress and restricts virus replication.
- Lysine 61 of ORF3 is a key ubiquitination site; mutation to arginine increases ORF3 stability, ER stress, and viral titer.
- This study identifies HERPUD1 as a novel host restriction factor against PEDV, offering insights for vaccine development.