Prasugrel inhibits TLR7-driven autoimmunity in systemic lupus erythematosus by acetylating cGAS - PubMed
5 hours ago
- #cGAS
- #Prasugrel
- #Systemic lupus erythematosus
- Prasugrel inhibits TLR7-driven autoimmunity in systemic lupus erythematosus (SLE) by acetylating cGAS.
- cGAS is significantly activated in SLE patients, and its deletion protects mice from lupus-like symptoms.
- Prasugrel disrupts DNA-triggered liquid phase condensation and activation of cGAS via direct acetylation.
- Prasugrel shows remarkable efficacy in treating SLE in both mouse models and patient cells.
- Elevated plasma cyclic GMP-AMP (cGAMP) in SLE patients may serve as a biomarker for predicting prasugrel response.