Channeling teamwork: ATP and lipids cooperate to gate P2X receptors - PubMed
4 hours ago
- #Lipid Environment
- #P2X Receptors
- #Channel Gating
- P2X receptor structures in lipid environments reveal subtype-specific ligand recognition, drug sensitivity, and channel gating mechanisms.
- Research focuses on P2X2 receptors in lipid nanodiscs to understand ligand recognition and channel opening.
- A novel antagonist NF449 shows picomolar potency at human P2X1 receptors, indicating potential therapeutic applications.