Hyaluronic Acid Decoration Facilitates CD44-Mediated Targeting and Alters Protein Corona Formation of Extracellular Vesicles - PubMed
6 hours ago
- #CD44 targeting
- #extracellular vesicles
- #protein corona
- Hyaluronic acid (HA) decoration on extracellular vesicles (EVs) enhances their uptake into CD44-expressing cells, particularly relevant in cancers and inflammatory diseases.
- HA-decorated EVs form a thicker protein corona with enriched plasma-derived components, altering corona composition compared to nondecorated EVs.
- CD44 expression is critical for increased uptake of HA-decorated EVs, but endocytosis mechanisms remain unchanged regardless of HA decoration.
- The study utilized microscopic methods to analyze EV uptake and multi-parametric surface plasmon resonance with mass spectrometry for protein corona analysis.
- Findings underscore HA's dual role in improving targeted delivery via CD44 and modulating EV interactions through protein corona formation.