Stage-Specific Degradation of Cyclin D3 Orchestrates Myelopoiesis and Restrains Myeloproliferative Neoplasms Development - PubMed
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- #MPN
- #myelopoiesis
- #cyclin D3
- Cyclin D3 degradation regulates myelopoiesis, preventing myeloproliferative neoplasms (MPN).
- Mice with degradation-resistant cyclin D3 (D3T283A) showed altered hematopoiesis, including enhanced granulocyte-monocyte differentiation and extramedullary hematopoiesis.
- D3T283A mutation increased HSPC self-renewal, competitive advantage, and drove MPN development, reducing survival.
- Stabilizing cyclin D2 (D2T280A) did not cause similar immunophenotypic changes.
- D3T283A upregulated FOXM1 and PRMT5 transcriptomic programs; targeting these suppressed myeloproliferation.