Monoclonal Gammopathies of Thrombotic and Hemorrhagic Significance: Mapping into a classification schema - PubMed
7 hours ago
- #thrombotic disorders
- #monoclonal gammopathies
- #hemorrhagic disorders
- Monoclonal gammopathies of clinical significance are non-malignant disorders affecting multiple or single organ systems.
- These disorders are driven by monoclonal proteins (MIg) from small B-cell or plasma cell clones.
- MIg can cause thrombotic and hemorrhagic complications through interactions with coagulation pathways, platelets, and vascular endothelium.
- Conditions include amyloidosis, cold agglutinin disease, M-protein-associated antiphospholipid antibody syndrome, and thrombotic microangiopathies.
- Proposal to classify these disorders as monoclonal gammopathies of thrombotic/hemorrhagic significance (MGTHS).
- Diagnostic approach includes evaluating alternative causes, characterizing the monoclonal protein, and assessing clinical features.
- Need for systematic recognition, diagnostic evaluation, and multidisciplinary management of MGTHS.