Probiotic Supplementation as an Adjuvant Therapy in Pediatric Drug-Resistant Epilepsy: A Double-Blind Placebo-Controlled Trial - PubMed
5 days ago
- #probiotics
- #epilepsy
- #neuroinflammation
- Probiotic supplementation (Lactobacillus acidophilus) was tested as an adjunctive therapy in pediatric drug-resistant epilepsy (DRE).
- The study was a randomized, double-blind, placebo-controlled trial involving 60 children with DRE.
- The probiotic group showed significant reductions in seizure frequency and improvements in quality of life (QOLCE-55 score).
- Serum levels of inflammatory markers (HMGB1, NLRP3, Hcy, IL-1β) decreased significantly in the probiotic group.
- The findings suggest probiotics may enhance conventional antiepileptic drug effectiveness and reduce systemic inflammation.
- Further validation is needed to confirm these results.