tRNA modifications in cancer: from molecular mechanisms to clinical translation - PubMed
5 hours ago
- #cancer biomarkers
- #tRNA modifications
- #clinical translation
- tRNA modifications are extensively studied and have significant roles in cancer.
- Defects in tRNA modifications and fragmentation are potential diagnostic biomarkers.
- Enzymes regulating tRNA function as oncogenes or tumor suppressors.
- tRNA modifications influence cancer progression, therapy resistance, and immune evasion.
- Research highlights therapeutic potential in targeting tRNA modification machinery.
- Challenges exist in translating tRNA modification knowledge to clinical practice.