Buccal Transmucosal Controlled Drug Delivery System: Emerging Strategy For Oral Antidiabetic Therapy - A Review - PubMed
5 hours ago
- #Buccal drug delivery
- #Diabetes treatment
- #Drug absorption
- Diabetes mellitus requires steady medical treatment, but standard oral medicines face issues like low absorption and liver breakdown.
- Buccal drug delivery, through the mouth lining, is a promising alternative that controls drug release and avoids liver breakdown.
- The review examines buccal mucosa's structure, drug-absorption capacity, and utility for drug delivery.
- Various systems like tablets, patches, films, gels, and sticky polymers are discussed for buccal drug delivery.
- Methods to enhance drug permeation through the mouth lining are explored.
- Buccal drug delivery's impact on diabetes drugs like Metformin and Glibenclamide is explained.
- Clinical benefits, recent research, and future opportunities with new technologies are highlighted.
- Limitations include poor absorption, mouth irritation, small absorption area, salivary washout, and low permeability.
- Oral diabetes medicines can irritate the stomach and intestines, complicating patient adherence.
- The review provides an overview of buccal drug delivery's potential to improve diabetes treatment.