Combination therapy with cetirizine and anti-PD-1 antibody suppresses colitis-induced colon tumor formation in mice - PubMed
3 days ago
- #cetirizine
- #tumor microenvironment
- #cancer immunotherapy
- Combination therapy with cetirizine and anti-PD-1 antibody reduces colitis-induced colon tumor formation in mice.
- Cetirizine enhances the antitumor effects of anti-PD-1 antibody, leading to reduced tumor volume and increased immune activation.
- The combination therapy results in elevated CD3+ T-cell infiltration into tumors and downregulation of genes like Vegfa, Mmp9, Il10, and Cd80.
- In vitro studies show cetirizine suppresses Mmp9 in CT26 cells, Il10 in macrophages, and VEGFA in endothelial cells.
- The findings suggest cetirizine reshapes the tumor microenvironment, improving the efficacy of immune checkpoint inhibitors.