Whole blood gene expression moderates associations between AD biomarkers and cognitive decline in cognitively unimpaired older adults - PubMed
10 hours ago
- #Gene Expression
- #Alzheimer's Disease
- #Cognitive Decline
- Study investigates how whole blood gene expression moderates the relationship between Alzheimer's disease (AD) biomarkers and cognitive decline in cognitively unimpaired older adults.
- Research involved 770 participants from the A4/LEARN studies, focusing on amyloid beta (Aβ) and tau-PET imaging as AD biomarkers.
- Identified protective and risk-related gene expression signatures, including interactions with Aβ-PET and tau-PET affecting cognitive decline.
- Findings highlight sex-differentiated pathways, with specific genes moderated by sex and AD biomarkers.
- Pathway enrichment analyses pointed to immunity, protein synthesis, and lipid metabolism as key areas influenced by gene expression.
- Emphasizes the role of peripheral transcriptomic markers in understanding preclinical AD and potential protective mechanisms against cognitive decline.