Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems - PubMed
4 hours ago
- #BCYRN1
- #organoids
- #stress circuitry
- Researchers developed human amygdala-like telencephalic organoids (hATOs) to model stress circuitry.
- hATOs were assembled with hypothalamic organoids to study amygdala-hypothalamus interactions.
- Exposure to cortisol upregulated BCYRN1, a primate-specific retrotransposon-derived noncoding RNA.
- This revealed a novel mechanism linking stress hormone signaling to retrotransposon biology and synaptic regulation.
- The model helps understand molecular features of affective circuitry in stress responses and disorders.