Heterogeneity and Clinical Relevance of Group 2 Innate Lymphoid Cells Subsets in Nasal Polyps - PubMed
6 hours ago
- #type 2 inflammation
- #ILC2 subsets
- #nasal polyps
- ILC2s in nasal polyps produce more IL-5 and IL-13 than Th2 cells, driving local type 2 inflammation.
- Four distinct ILC2 subsets were identified: migratory, transitional, inflammatory, and exhausted-like, each reflecting different activation states.
- The combined count of transitional, inflammatory, and exhausted-like subsets correlates with CT scores, and inflammatory and exhausted-like subsets are linked to clinical symptom severity.