[Bone marrow infiltration of large B-cell lymphoma with clinical manifestations similar to systemic lupus erythematosus: A case report] - PubMed
4 hours ago
- #differential diagnosis
- #bone marrow lymphoma
- #systemic lupus erythematosus
- An elderly female presented with edema and bilateral lower limb fatigue, initially treated for hypothyroidism and hypoproteinemia.
- Laboratory findings included anemia, thrombocytopenia, elevated LDH, abnormal coagulation, positive urinary protein, reduced complement C3 and C4, and positive antinuclear antibodies, leading to a suspected diagnosis of SLE.
- After glucocorticoid treatment, symptoms partially improved but fatigue worsened, and inconsistent responses prompted further investigation.
- Bone marrow puncture revealed large B-cell lymphoma with 27.5% tumor cell infiltration, classified as bone marrow lymphoma (BML), specifically primary bone marrow lymphoma (PBML), without lymph node or organ enlargement.
- The case underscores the importance of revisiting diagnosis when treatment response is inconsistent, as the patient died within two months from symptom onset, highlighting the poor prognosis of BML and need for rapid diagnosis.