Modulating immune response for the prevention and treatment of type 1 diabetes - PubMed
6 hours ago
- #islet transplantation
- #immunomodulation
- #type 1 diabetes
- Type 1 diabetes (T1D) is characterized by autoimmune destruction of pancreatic β-cells, leading to insulin deficiency.
- Recent discoveries have improved understanding of T1D pathogenesis and its progression stages.
- FDA-approved drugs for T1D prevention highlight the potential of early intervention therapies.
- Islet transplantation can achieve long-term insulin independence but requires lifelong immunosuppression, increasing risks of infections and malignancies.
- Immunomodulation approaches for T1D prevention include antigen-specific therapies, immune blockade, and cell-based therapies.
- Advances in islet replacement strategies involve islet engineering, device encapsulation, and immunomodulatory biomaterials to reduce immunosuppression needs.
- The review provides a comprehensive overview of current immunomodulatory therapies for T1D prevention and treatment.