Characteristics and Prognosis of Early-Onset vs. Late-Onset Colon Cancer: A Propensity Score Matching Analysis Based on Histology - PubMed
12 hours ago
- #prognosis
- #histology
- #colon cancer
- Study evaluates the influence of age at diagnosis and histologic subtype on colon cancer prognosis using SEER database data from 180,804 patients.
- Patients were stratified into early-onset and late-onset groups, with histology types being adenocarcinoma or mucinous adenocarcinoma.
- Early-onset colon cancer was associated with more advanced tumor stages.
- Propensity score matching was used to balance cohorts for survival analyses (CSS and SSS).
- Early-onset adenocarcinoma patients had the most favorable cancer-specific and surgery-specific survival.
- Late-onset mucinous adenocarcinoma patients experienced the worst outcomes.
- No significant age-related differences were found when stratified by histology.
- Nonmetastatic early-onset adenocarcinoma showed significantly poorer surgery-specific survival compared to late-onset adenocarcinoma.
- Findings highlight the need to integrate age and histologic type for accurate prognostic assessment and personalized treatment strategies.