Primary sclerosing cholangitis - PubMed
6 hours ago
- #Liver disease
- #Primary sclerosing cholangitis
- #Inflammatory bowel disease
- Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease.
- Characterized by biliary inflammation and fibrosis, with 50-80% co-occurrence of inflammatory bowel disease.
- Increased risk for hepatobiliary and colorectal cancers.
- Presentation varies but includes progressive bile duct fibrosis, strictures, liver fibrosis, cirrhosis, and potential liver transplantation.
- Diagnosis often occurs at an asymptomatic stage; symptoms include itching, fatigue, abdominal pain, cholangitis, and portal hypertension complications.
- Limited treatment options; exact cause and pathogenesis remain unclear, with genetic, environmental, and microbiome factors implicated.
- Highlights the clinical features, pathogenesis understanding, and management challenges of PSC.