RYK is a GPNMB receptor that drives MASH - PubMed
4 days ago
- #MASH
- #therapeutic target
- #GPNMB-RYK axis
- RYK is identified as a receptor for GPNMB, driving metabolic-dysfunction-associated steatohepatitis (MASH).
- GPNMB's secreted ectodomain (G-ECD), not full-length GPNMB, promotes MASH progression.
- Serum G-ECD levels correlate with MASH severity in human patients.
- RYK ablation in hepatocytes protects mice from MASH by blocking G-ECD effects.
- G-ECD binding to RYK activates ERK1/2 signaling, leading to PPARγ-CD36 and SREBP1C pathway activation.
- Therapeutic strategies targeting the GPNMB-RYK axis show promise in preventing and treating MASH.