Epididymal macrophage senescence contributes to sperm motility decrease upon environmental stress - PubMed
5 hours ago
- #sperm motility
- #male infertility
- #macrophage senescence
- Environmental stressors like lead, cadmium, and mercury reduce sperm motility.
- Epididymal macrophage senescence is induced by environmental stress, contributing to decreased sperm motility.
- Clearing senescent epididymal macrophages alleviates stress-induced sperm motility reduction.
- Environmental stress down-regulates Foxo3 expression in macrophages, leading to senescence.
- Increased Foxo3 N6-methyladenosine levels and inhibited FTO are key mechanisms in stress-induced macrophage senescence.
- Overexpression of Fto and S-adenosylhomocysteine supplementation can alleviate macrophage senescence.
- Targeting senescent epididymal macrophages may offer a new strategy to prevent male infertility.