Targeting Fatty Acids in Liver Cancer: Molecular Insights and Drug Approaches - PubMed
5 hours ago
- #drug resistance
- #liver cancer
- #fatty acid metabolism
- Primary liver cancer (PLC), including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), is highly aggressive with poor prognosis.
- Dysregulation of fatty acid metabolism plays a crucial role in HCC progression and therapeutic resistance.
- Key alterations include increased fatty acid transporters, reprogramming of de novo lipogenesis, and altered fatty acid oxidation.
- These changes upregulate oncogenic signaling pathways and help PLC cells adapt to nutrient-deprived conditions.
- Fatty acid metabolism also affects immune cell function and angiogenesis, shaping the tumor microenvironment.
- The review discusses promising druggable targets, their status in clinical trials, and challenges in targeting fatty acid metabolism.
- Precision therapies focusing on fatty acid metabolism could be integrated with current treatments.