Porphyromonas gingivalis secreted factors drive epithelial-mesenchymal transition (EMT) through gingipains and an H2S-mediated bacterial defense system - PubMed
5 hours ago
- #epithelial-mesenchymal transition
- #colorectal cancer
- #Porphyromonas gingivalis
- Porphyromonas gingivalis (P. gingivalis) is linked to colorectal cancer (CRC) progression.
- Secreted factors from P. gingivalis modulate Wnt/β-catenin and Hippo-YAP signaling pathways.
- Cysteine proteases (Kgp and RgpA) and H₂S induce epithelial-mesenchymal transition (EMT) markers.
- EMT induction leads to cell detachment and increased motility, promoting CRC neoplasia.
- The study reveals a novel connection between microbial virulence and host cell transformation.