NPC1 promotes HTNV replication by controlling innate immune response - PubMed
5 hours ago
- #Hantaan virus
- #Innate Immunity
- #NPC1 protein
- NPC1 interacts with HTNV glycoprotein GP and promotes viral replication.
- NPC1 suppresses the innate immune response during HTNV infection.
- This study used deep learning screening and IP-MS to identify NPC1 as a host factor.
- NPC1's role in dampening antiviral immunity is a novel function not previously reported.
- The findings suggest NPC1 as a potential target for antiviral therapy against HTNV.