Intratumor Heterogeneity and Clonal Evolution in Sarcomas: Molecular, Cellular, and Functional Drivers of Therapy Resistance - PubMed
7 days ago
- #sarcoma
- #therapy resistance
- #intratumor heterogeneity
- Sarcomas are malignant neoplasms of mesenchymal origin with over 100 entities and subtypes.
- Intratumor heterogeneity (ITH) and clonal evolution in sarcomas contribute to therapy resistance.
- Single-cell and spatial omics technologies provide detailed insights into sarcoma architecture.
- Five representative sarcoma types are discussed: osteosarcoma, dedifferentiated liposarcoma, Ewing sarcoma, synovial sarcoma, and alveolar rhabdomyosarcoma.
- Clonal and subclonal molecular alterations, oncogene activity fluctuations, and cellular plasticity drive sarcoma progression.
- Recent advances in modeling ITH and evaluating functional diversity are reviewed.
- Future directions in ITH research and clinical implications are outlined.