Plasma-derived exosomes from obese knee osteoarthritis aggravate synovitis by promoting cellular senescence of synovial fibroblasts - PubMed
7 hours ago
- #Cellular Senescence
- #Osteoarthritis
- #Exosomes
- Plasma-derived exosomes from obese knee osteoarthritis (OA) patients aggravate synovitis by promoting cellular senescence of synovial fibroblasts.
- Obesity is a significant risk factor for knee OA, correlating with clinical symptoms and disease severity.
- Study analyzed exosomal RNA signatures in plasma of OA patients with different BMI levels, revealing differential expression of miRNAs, lncRNAs, and mRNAs.
- Intra-articular injection of exosomes from obese OA patients (EXOsObese) worsened synovial fibroblast senescence and synovitis in mice models.
- miR-192-5p in EXOsObese was found to promote cellular senescence by inhibiting autophagy via targeting ATG7.
- Findings suggest plasma-derived exosomes, particularly those from obese patients, exacerbate OA synovitis through fibroblast senescence, highlighting potential therapeutic targets like miR-192-5p.