Exercise training alleviates myocardial injury in mice with heart failure with preserved ejection fraction via the TLR4-mediated necroptosis pathway - PubMed
5 hours ago
- #TLR4
- #HFpEF
- #Exercise Training
- Exercise training (HIIT and MICT) improves cardiac function in HFpEF mice.
- HIIT shows more pronounced effects than MICT in alleviating HFpEF symptoms.
- Exercise training reduces myocardial injury by inhibiting TLR4-mediated necroptosis.
- Transcriptomic profiling identifies necroptosis as a key pathway affected by exercise.
- TLR4 knockdown in cardiomyocytes suppresses necroptosis and improves mitochondrial function.
- Targeting TLR4 and necroptosis may offer therapeutic benefits for HFpEF patients.